About
I am a dermatologist with a Doctorate of Medicine and a university lecturer at the Faculty of Medicine at ‘Carol Davila’ University of Medicine and Pharmacy in Bucharest. In addition to an extensive medical teaching career, I am also a scientific researcher at the Department of Ultrastructural Pathology for the ‘Victor Babeș’ National Institute of Pathology in Bucharest.
Dermatology is the branch of medicine that comprises the physiology (health) and pathology (disease) of the integumentary system, commonly known as our skin. The field also includes understanding the skin together with the epidermal facets of nails and hair.
The skin, the cutaneous organ, represents in quantifiable terms, the largest, most extended, heaviest organ of the human body. Moreover, the skin is located at the periphery of our body and represents our interface with the surrounding world. These are just a few characteristics that give the skin a series of functions: mechanical barrier, endocrine function, exocrine function, metabolic function, and social function.
The loss or disturbance of the structural, functional, or metabolic integrity of the skin, partially or totally, leads to various dermatological pathologies, some with serious repercussions on the whole person and their state of health. In addition, our social relationships are favored, to some extent, by the appearance of our skin. Because of this, I think it's safe to say that skin that looks good is skin that gives you (at least in some situations) some advantages.
The prevention of skin disease constitutes a significant share of dermatological activity. Dermatology covers a myriad of several thousand distinct dermatological conditions and circumstances, between which the threshold of detection is sometimes extremely subtle, almost imperceptible clinically, or sometimes ambiguous even to dermoscopy. Often, for a correct dermatological diagnosis to choose an optimal, targeted, and effective therapeutic approach to treat the skin condition in question, it is necessary to biopsy the skin with a secondary dermatopathological examination. With the experience I’ve gained in my comprehensive teaching and research activities of the structural and ultrastructural cutaneous morphology and my collaboration with reputable dermato-pathologists, I have gained the expertise to interpret the biopsies performed and make an informed decision on the investigated cases. In addition to my broad clinical experience in the diagnosis, prevention, and management of dermatological and venereological pathologies, I also work on the effective management of various structural, chromatic, physiological and pathological textural skin defects - this statement is supported by the more than 25.000 treated cases. Every patient is unique, and a full day of consultations presents complex medical examinations with varied dermatological problems. In addition to the phenotypic features presented and their genotypic background, communication with the patient and their relatives is key to making a good diagnosis. With the trust of each patient, I believe it is my duty to be super-specialized, always up to date with the latest topics and approaches in the field, adapted to the most recent working protocols. Every professional consideration must be supported by premium infrastructure, and I am fortunate to collaborate with all the top clinics in Bucharest. Remember, beautiful skin is healthy skin!
I am a dermatologist with a Doctorate of Medicine and a university lecturer at the Faculty of Medicine at ‘Carol Davila’ University of Medicine and Pharmacy in Bucharest. In addition to an extensive medical teaching career, I am also a scientific researcher at the Department of Ultrastructural Pathology for the ‘Victor Babeș’ National Institute of Pathology in Bucharest.
Dermatology is the branch of medicine that comprises the physiology (health) and pathology (disease) of the integumentary system, commonly known as our skin. The field also includes understanding the skin together with the epidermal facets of nails and hair.
The skin, the cutaneous organ, represents in quantifiable terms, the largest, most extended, heaviest organ of the human body. Moreover, the skin is located at the periphery of our body and represents our interface with the surrounding world. These are just a few characteristics that give the skin a series of functions: mechanical barrier, endocrine function, exocrine function, metabolic function, and social function.
The loss or disturbance of the structural, functional, or metabolic integrity of the skin, partially or totally, leads to various dermatological pathologies, some with serious repercussions on the whole person and their state of health. In addition, our social relationships are favored, to some extent, by the appearance of our skin. Because of this, I think it's safe to say that skin that looks good is skin that gives you (at least in some situations) some advantages.
The prevention of skin disease constitutes a significant share of dermatological activity. Dermatology covers a myriad of several thousand distinct dermatological conditions and circumstances, between which the threshold of detection is sometimes extremely subtle, almost imperceptible clinically, or sometimes ambiguous even to dermoscopy. Often, for a correct dermatological diagnosis to choose an optimal, targeted, and effective therapeutic approach to treat the skin condition in question, it is necessary to biopsy the skin with a secondary dermatopathological examination. With the experience I’ve gained in my comprehensive teaching and research activities of the structural and ultrastructural cutaneous morphology and my collaboration with reputable dermato-pathologists, I have gained the expertise to interpret the biopsies performed and make an informed decision on the investigated cases. In addition to my broad clinical experience in the diagnosis, prevention, and management of dermatological and venereological pathologies, I also work on the effective management of various structural, chromatic, physiological and pathological textural skin defects - this statement is supported by the more than 25.000 treated cases. Every patient is unique, and a full day of consultations presents complex medical examinations with varied dermatological problems. In addition to the phenotypic features presented and their genotypic background, communication with the patient and their relatives is key to making a good diagnosis. With the trust of each patient, I believe it is my duty to be super-specialized, always up to date with the latest topics and approaches in the field, adapted to the most recent working protocols. Every professional consideration must be supported by premium infrastructure, and I am fortunate to collaborate with all the top clinics in Bucharest. Remember, beautiful skin is healthy skin!
Competencies
-
DermoscopyMicroscopie de epiluminiscență cutanată. Reprezintă o metodă de examinare a leziunilor cutanate folosind dermatoscopul (un instrument optic de mărire care conține și sursa de lumină polarizată sau non-polarizată), și care permite obținerea de detalii vizuale cruciale în diagnosticul multor tipuri de leziuni cutanate (în special cancere de piele).
-
Lasers in dermatologyL.A.S.E.R. – Light Amplification by Stimulated Emission of Radiation – laserele dermatologice reprezintă o realitate terapeutica de multa vreme. Multe afecțiuni cutanate (dar nu toate) pot beneficia de tratamente laser cu rezultate terapeutice si cosmetice superioare. Oportunitatea folosirii laserului în tratamentul afecțiunilor dermatologice se stabilește numai in urma unui consult medical efectuat în cabinet.
-
Dermatological surgeryChirurgia dermatologică reprezintă o subspecialitate a chirurgiei care tratează anumite condiții / afecțiuni cutanate. Este o punte disciplinară între dermatologie și chirurgie plastică. De cele mai multe ori implică excizia chirurgicală a diverselor leziuni cutanate și/sau reconstrucții tegumentare prin diverse proceduri reconstructive chirurgicale.
-
DermatocosmeticsDermatocosmetica este acea ramură a dermatologiei care cu ajutorul produselor farmacologice și/sau dermatocosmetice interesează tratamentul pielii în vederea menținerii sănătății și aspectului acesteia, dar și tratamentul afecțiunilor superficiale cutanate: defecte structurale superficiale cutanate (cicatrice, riduri, etc), discromii cutanate.
Areas of dermatological clinical interest
- General DermatoVenerology
- Prevention
- Diagnostic
- Dermatological screening
- Skin cancer
- Dermoscopy
- DermatoEsthetics
- Skin rejuvenation
- Dermatological treatment
- Focused cryotherapy
- Laser therapies (CO2, CO2 MT, RedTouch Lasers, vascular, pigmentary – long and short pulsed Nd: YAG)
Areas of interest in biomedical research
- The latest and innovative diagnostic methods
- Therapeutic implications of new molecular targets
- Translational medicine
- Regenerative medicine
- Precision medicine
- Cell cultures for various cell populations (interstitial cells, epithelial cells)
- Laboratory flow-cytometric analysis
- Laboratory experimental models in vivo
- Laboratory experimental techniques of cardiac and mediastinal microsurgery
- Cell transplantation of cardiac stem cells and interstitial cells on pathological heart tissue
- Laboratory experimental echocardiographic investigation
- Different techniques of optical microscopy and electron microscopy
- Interpretation and analysis of the results of histology, immunohistochemistry, immunofluorescence, confocal microscopy, transmission electron microscopy, electron microscopy with tomography. Clinical skills in DermatoVenerology: dermoscopy, skin biopsies, radiofrequency techniques in various pathologies and dermatological therapies and dermatological lasers
Postgraduate studies
- CONSULTANT DERMATOVENEROLOGIST – "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania
- DERMATOVENEROLOGY SPECIALIST DOCTOR – "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania
- POSTDOCTORAL STUDIES – National Institute of Pathology "Victor Babeș", Bucharest, Romania
- MEDICAL GENETICS SPECIALIST - "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania
- DOCTOR OF MEDICINE – "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania
- MASTER IN HEALTH SERVICES MANAGEMENT – Academy of Economic Sciences, Bucharest, Romania
- MEDICAL DOCTOR - Faculty of General Medicine, "Ovidius" University, Constanța, Romania
- BACHELOR'S DEGREE (profile: Computer Sciences) – "Ovidius" Theoretical High School, Constanța, Romania
Courses / Training /
Workshops
- “Increasing patient satisfaction.” Radcliffe Learning. (Bucharest, 2012)
- “Skills to increase patient satisfaction - for doctors.” (Bucharest, 2012)
- “Global approach in facial rejuvenation, hyaluronic acid injection, regeneration with autologous cells, microneedle therapy.” (Bucharest, 2014)
- “Dermato-esthetics course.” (Iassy, 2014)
- Dermatology School - Iassy Dermatological Spring (Iassy, 2014)
- “Updates in the Management of Melanoma.” European School of Oncology (Bucharest, 2014)
- “Aesthetic medicine course - injectable AH on the face and neck.” (Bucharest, 2016)
- “Practical notions of dermoscopy” (Iassy, 2018)
- Quanta Systems Training Academy with Dermatological Lasers / Q-Plus Series, Thunder / Duetto Series, 585, Youlaser MT (Viterbo, Italy, 2019)
- Deka Laser Academy Training Course with CO2 laser, Alexandrite, Nd: YAG lasers (Florence, Italy, 2019)
- “Skin plastics with fillers.” Association of Plastic Surgeons of Romania (Brașov, Romania, 2022)
- Restylane – Galderma Aesthetic Injector Network Share Experience Meeting (Bucharest, Romania, 2022)
- International Master Course on Aging Science (Paris, France, 2023)
- Applications of ultrasonography in dermatology and cosmetology (Bucharest, Romania, 2025)
Scientific activity
- Member of a working team of 11 national and European research projects, and also a director of a national research project in the field of regenerative medicine and innovative therapies.
- Invited speaker at numerous national and international scientific events (Europe and Asia).
- Seven national and international awards or distinctions.
Guest Editor of several Special Issues hosted by prominent ISI medical Journals
- Physiology of Telocytes – A special issue of Cells. This special issue belongs to the section „Cellular Pathology”.
https://www.mdpi.com/journal/cells/special_issues/8EQ794320T - Cutaneous Melanoma: Updating from Pathogenesis to Therapy. This special issue belongs to the section "Dermatology".
https://www.mdpi.com/journal/medicina/special_issues/P594V00008
Publications
- I am the author or co-author of numerous original scientific articles, including more than 20 articles or abstracts published in international journals with an ISI Impact Factor over 4, and indexed in national and international databases. According to the Thompson-Reuters ISI Web of Science, the current impact and relevance of these published works are quantified internationally by a Hirsch Index of 15, which signifies published works totaling more than 1500 citations in the Thompson-Reuters ISI system. I have also co-authored selected book chapters in the field of histology, genetics and dermatology, which were included in medical treatises published by prestigious national and international publishing houses.
- 1. Skin Telocytes Could Fundament the Cellular Mechanisms of Wound Healing in Platelet-Rich Plasma Administration. Manole CG, Voiculescu VM, Soare C, Ceafalan LC, Gherghiceanu M, Hinescu ME.Cells. 2024 Aug 8;13(16):1321. doi: 10.3390/cells13161321.
https://www.mdpi.com/2073-4409/13/16/1321 - 2. Correlation between high-risk HPV infection and p16/Ki-67 abnormalities in Pap samples in a South Eastern Europe cohort. Shalaby NA, Tudorescu-Morjan C, Manole CG, Iacata AA, Popovici ML, Grecu LI, Curici A.J Med Virol. 2024 Mar; 96(3):e29524. doi: 10.1002/jmv.29524.
https://onlinelibrary.wiley.com/doi/10.1002/jmv.29524 - 3. Manole CG, Soare C, Ceafalan LC, Voiculescu VM. Platelet-Rich Plasma in Dermatology: New Insights on the Cellular Mechanism of Skin Repair and Regeneration. Life (Basel). 2023 Dec 25;14(1):40.
doi: 10.3390/life14010040.
https://www.mdpi.com/2075-1729/14/1/40 - 4. Manole CG, Gherghiceanu M, Ceafalan LC, Hinescu ME. Dermal telocytes: a different viewpoint of skin repairing and regeneration. Cells. 2022; 11(23): 3903.
doi: 10.3390/cells11233903.
https://www.mdpi.com/2073-4409/11/23/3903 - 5. Cucu I, Nicolescu MI, Busnatu ȘS, Manole CG. Dynamic involvement of telocytes in modulating multiple signaling pathways in cardiac cytoarchitecture. Int J Mol Sci. 2022; 23(10):5769. doi: 10.3390/ijms23105769.
https://www.mdpi.com/1422-0067/23/10/5769 - 6. Manole CG, Marinescu BG, Marta D, Nicolescu MI. Areas of cartilaginous and osseous metaplasia after experimental myocardial infarction in rats. Anat Rec (Hoboken). 2019; 302(6): 947-953. doi: 10.1002/ar.24010.
https://anatomypubs.onlinelibrary.wiley.com/doi/10.1002/ar.24010 - 7. Galrinho RD, Manole CG, Vinereanu D. Telocytes – a hope for cardiac repair after myocardial infarction. Maedica (Bucur). 2016; 11(4): 325-329.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5543526/pdf/maedica-11-325.pdf - 8. Manole CG, Simionescu O. The cutaneous telocytes. Adv Exp Med Biol. 2016; 913: 303-323. doi: 10.1007/978-981-10-1061-3_20.
https://link.springer.com/chapter/10.1007/978-981-10-1061-3_20 - 9. Manole CG, Cretoiu D. In memoriam: Professor Laurentiu M. Popescu (1944-2015). Clin Transl Med. 2015; 4(1): 29. doi: 10.1186/s40169-015-0070-5.
https://clintransmed.springeropen.com/articles/10.1186/s40169-015-0070-5 - 10. Kang Y, Zhu Z, Zheng Y, Wan W, Manole CG, Zhang Q. Skin telocytes versus fibroblasts: two distinct dermal cell populations. J Cell Mol Med. 2015; 19(11): 2530-9. doi: 10.1111/jcmm.12671.
https://onlinelibrary.wiley.com/doi/10.1111/jcmm.12671 - 11. Manole CG, Gherghiceanu M, Simionescu O. Telocyte dynamics in psoriasis. J Cell Mol Med. 2015; 19(7): 1504-19. doi: 10.1111/jcmm.12601.
https://onlinelibrary.wiley.com/doi/10.1111/jcmm.12601 - 12. Drăgoi Galrinho R, Ciobanu AO, Rimbas RC, Manole CG, Leena BM, Vinereanu D. New echocardiographic protocol for the assessment of experimental myocardial infarction in rats. Maedica (Bucur). 2015; 10(2): 85-90.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5327796/pdf/maedica-10-85.pdf - 13. Chen X, Zheng Y, Manole CG, Wang X, Wang Q. Telocytes in human oesophagus. J Cell Mol Med. 2013; 17(11): 1506-12. doi: 10.1111/jcmm.12149.
https://onlinelibrary.wiley.com/doi/10.1111/jcmm.12149 - 14. Qi G, Lin M, Xu M, Manole CG, Wang X, Zhu T. Telocytes in the human kidney cortex. J Cell Mol Med. 2012; 16(12): 3116-22. doi: 10.1111/j.1582-4934.2012.01582.x.
https://onlinelibrary.wiley.com/doi/10.1111/j.1582-4934.2012.01582.x - 15. Manole CG, Cismaşiu V, Gherghiceanu M, Popescu LM. Experimental acute myocardial infarction: telocytes involvement in neo-angiogenesis. J Cell Mol Med. 2011; 15(11): 2284-96. doi: 10.1111/j.1582-4934.2011.01449.x.
https://onlinelibrary.wiley.com/doi/10.1111/j.1582-4934.2011.01449.x - 16. Zheng Y, Li H, Manole CG, Sun A, Ge J, Wang X. Telocytes in trachea and lungs. J Cell Mol Med. 2011 Oct;15(10):2262-8. doi: 10.1111/j.1582-4934.2011.01404.x. PMID: 21810171; PMCID: PMC4394233.
https://onlinelibrary.wiley.com/doi/10.1111/j.1582-4934.2011.01404.x - 17. Popescu LM, Gherghiceanu M, Suciu LC, Manole CG, Hinescu ME. Telocytes and putative stem cells in the lungs: electron microscopy, electron tomography and laser scanning microscopy. Cell Tissue Res. 2011 Sep;345(3):391-403. doi: 10.1007/s00441-011-1229-z.
https://link.springer.com/article/10.1007/s00441-011-1229-z - 18. Enciu AM, Nicolescu MI, Manole CG, Mureşanu DF, Popescu LM, Popescu BO. Neuroregeneration in neurodegenerative disorders. BMC Neurol. 2011; 11: 75. doi: 10.1186/1471-2377-11-75.
https://bmcneurol.biomedcentral.com/articles/10.1186/1471-2377-11-75 - 19. Popescu LM, Manole E, Serboiu CS, Manole CG, Suciu LC, Gherghiceanu M, Popescu BO. Identification of telocytes in skeletal muscle interstitium: implication for muscle regeneration. J Cell Mol Med. 2011; 15(6): 1379-92. doi: 10.1111/j.1582-4934.2011.01330.x.
https://onlinelibrary.wiley.com/doi/10.1111/j.1582-4934.2011.01330.x - 20. Gherghiceanu M, Manole CG, Popescu LM. Telocytes in endocardium: electron microscope evidence. J Cell Mol Med. 2010; 14(9): 2330-4. doi: 10.1111/j.1582-4934.2010.01133.x.
https://onlinelibrary.wiley.com/doi/10.1111/j.1582-4934.2010.01133.x - 21. Popescu LM, Manole CG, Gherghiceanu M, Ardelean A, Nicolescu MI, Hinescu ME, Kostin S. Telocytes in human epicardium. J Cell Mol Med. 2010; 14(8): 2085-93. doi: 10.1111/j.1582-4934.2010.01129.x.
https://onlinelibrary.wiley.com/doi/10.1111/j.1582-4934.2010.01129.x - 22. Popescu LM, Gherghiceanu M, Manole CG, Faussone-Pellegrini MS. Cardiac renewing: interstitial Cajal-like cells nurse cardiomyocyte progenitors in epicardial stem cell niches. J Cell Mol Med. 2009; 13(5): 866-86. doi: 10.1111/j.1582-4934.2009.00758.x.
https://onlinelibrary.wiley.com/doi/10.1111/j.1582-4934.2009.00758.x - 23. Suciu L, Popescu LM, Regalia T, Ardelean A, Manole CG. Epicardium: interstitial Cajal-like cells (ICLC) highlighted by immunofluorescence. J Cell Mol Med. 2009 Apr;13(4):771-7. doi: 10.1111/j.1582-4934.2009.00756.x.
https://onlinelibrary.wiley.com/doi/10.1111/j.1582-4934.2009.00756.x
Member of
- Bucharest Medical Council
- Romanian Medical Council
- Romanian Society of Dermatology
Competencies
-
DermoscopyMicroscopie de epiluminiscență cutanată. Reprezintă o metodă de examinare a leziunilor cutanate folosind dermatoscopul (un instrument optic de mărire care conține și sursa de lumină polarizată sau non-polarizată), și care permite obținerea de detalii vizuale cruciale în diagnosticul multor tipuri de leziuni cutanate (în special cancere de piele).
-
Lasers in dermatologyL.A.S.E.R. – Light Amplification by Stimulated Emission of Radiation – laserele dermatologice reprezintă o realitate terapeutica de multa vreme. Multe afecțiuni cutanate (dar nu toate) pot beneficia de tratamente laser cu rezultate terapeutice si cosmetice superioare. Oportunitatea folosirii laserului în tratamentul afecțiunilor dermatologice se stabilește numai in urma unui consult medical efectuat în cabinet.
-
Dermatological surgeryChirurgia dermatologică reprezintă o subspecialitate a chirurgiei care tratează anumite condiții / afecțiuni cutanate. Este o punte disciplinară între dermatologie și chirurgie plastică. De cele mai multe ori implică excizia chirurgicală a diverselor leziuni cutanate și/sau reconstrucții tegumentare prin diverse proceduri reconstructive chirurgicale.
-
DermatocosmeticsDermatocosmetica este acea ramură a dermatologiei care cu ajutorul produselor farmacologice și/sau dermatocosmetice interesează tratamentul pielii în vederea menținerii sănătății și aspectului acesteia, dar și tratamentul afecțiunilor superficiale cutanate: defecte structurale superficiale cutanate (cicatrice, riduri, etc), discromii cutanate.
Areas of dermatological clinical interest
- General DermatoVenerology
- Prevention
- Diagnostic
- Dermatological screening
- Skin cancer
- Dermoscopy
- DermatoEsthetics
- Skin rejuvenation
- Dermatological treatment
- Focused cryotherapy
- Laser therapies (CO2, CO2 MT, RedTouch Lasers, vascular, pigmentary – long and short pulsed Nd: YAG)
Areas of interest in biomedical research
- The latest and innovative diagnostic methods
- Therapeutic implications of new molecular targets
- Translational medicine
- Regenerative medicine
- Precision medicine
- Cell cultures for various cell populations (interstitial cells, epithelial cells)
- Laboratory flow-cytometric analysis
- Laboratory experimental models in vivo
- Laboratory experimental techniques of cardiac and mediastinal microsurgery
- Cell transplantation of cardiac stem cells and interstitial cells on pathological heart tissue
- Laboratory experimental echocardiographic investigation
- Different techniques of optical microscopy and electron microscopy
- Interpretation and analysis of the results of histology, immunohistochemistry, immunofluorescence, confocal microscopy, transmission electron microscopy, electron microscopy with tomography. Clinical skills in DermatoVenerology: dermoscopy, skin biopsies, radiofrequency techniques in various pathologies and dermatological therapies and dermatological lasers
Postgraduate studies
- CONSULTANT DERMATOVENEROLOGIST – "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania
- DERMATOVENEROLOGY SPECIALIST DOCTOR – "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania
- POSTDOCTORAL STUDIES – National Institute of Pathology "Victor Babeș", Bucharest, Romania
- MEDICAL GENETICS SPECIALIST - "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania
- DOCTOR OF MEDICINE – "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania
- MASTER IN HEALTH SERVICES MANAGEMENT – Academy of Economic Sciences, Bucharest, Romania
- MEDICAL DOCTOR - Faculty of General Medicine, "Ovidius" University, Constanța, Romania
- BACHELOR'S DEGREE (profile: Computer Sciences) – "Ovidius" Theoretical High School, Constanța, Romania
Courses / Training /
Workshops
- “Increasing patient satisfaction.” Radcliffe Learning. (Bucharest, 2012)
- “Skills to increase patient satisfaction - for doctors.” (Bucharest, 2012)
- “Global approach in facial rejuvenation, hyaluronic acid injection, regeneration with autologous cells, microneedle therapy.” (Bucharest, 2014)
- “Dermato-esthetics course.” (Iassy, 2014)
- Dermatology School - Iassy Dermatological Spring (Iassy, 2014)
- “Updates in the Management of Melanoma.” European School of Oncology (Bucharest, 2014)
- “Aesthetic medicine course - injectable AH on the face and neck.” (Bucharest, 2016)
- “Practical notions of dermoscopy” (Iassy, 2018)
- Quanta Systems Training Academy with Dermatological Lasers / Q-Plus Series, Thunder / Duetto Series, 585, Youlaser MT (Viterbo, Italy, 2019)
- Deka Laser Academy Training Course with CO2 laser, Alexandrite, Nd: YAG lasers (Florence, Italy, 2019)
- “Skin plastics with fillers.” Association of Plastic Surgeons of Romania (Brașov, Romania, 2022)
- Restylane – Galderma Aesthetic Injector Network Share Experience Meeting (Bucharest, Romania, 2022)
- International Master Course on Aging Science (Paris, France, 2023)
- Applications of ultrasonography in dermatology and cosmetology (Bucharest, Romania, 2025)
Scientific activity
- Member of a working team of 11 national and European research projects, and also a director of a national research project in the field of regenerative medicine and innovative therapies.
- Invited speaker at numerous national and international scientific events (Europe and Asia).
- Seven national and international awards or distinctions.
Guest Editor of several Special Issues hosted by prominent ISI medical Journals
- Physiology of Telocytes – A special issue of Cells. This special issue belongs to the section „Cellular Pathology”.
https://www.mdpi.com/journal/cells/special_issues/8EQ794320T - Cutaneous Melanoma: Updating from Pathogenesis to Therapy. This special issue belongs to the section "Dermatology".
https://www.mdpi.com/journal/medicina/special_issues/P594V00008
Publications
- I am the author or co-author of numerous original scientific articles, including more than 20 articles or abstracts published in international journals with an ISI Impact Factor over 4, and indexed in national and international databases. According to the Thompson-Reuters ISI Web of Science, the current impact and relevance of these published works are quantified internationally by a Hirsch Index of 15, which signifies published works totaling more than 1500 citations in the Thompson-Reuters ISI system. I have also co-authored selected book chapters in the field of histology, genetics and dermatology, which were included in medical treatises published by prestigious national and international publishing houses.
- 1. Skin Telocytes Could Fundament the Cellular Mechanisms of Wound Healing in Platelet-Rich Plasma Administration. Manole CG, Voiculescu VM, Soare C, Ceafalan LC, Gherghiceanu M, Hinescu ME.Cells. 2024 Aug 8;13(16):1321. doi: 10.3390/cells13161321.
https://www.mdpi.com/2073-4409/13/16/1321 - 2. Correlation between high-risk HPV infection and p16/Ki-67 abnormalities in Pap samples in a South Eastern Europe cohort. Shalaby NA, Tudorescu-Morjan C, Manole CG, Iacata AA, Popovici ML, Grecu LI, Curici A.J Med Virol. 2024 Mar; 96(3):e29524. doi: 10.1002/jmv.29524.
https://onlinelibrary.wiley.com/doi/10.1002/jmv.29524 - 3. Manole CG, Soare C, Ceafalan LC, Voiculescu VM. Platelet-Rich Plasma in Dermatology: New Insights on the Cellular Mechanism of Skin Repair and Regeneration. Life (Basel). 2023 Dec 25;14(1):40.
doi: 10.3390/life14010040.
https://www.mdpi.com/2075-1729/14/1/40 - 4. Manole CG, Gherghiceanu M, Ceafalan LC, Hinescu ME. Dermal telocytes: a different viewpoint of skin repairing and regeneration. Cells. 2022; 11(23): 3903.
doi: 10.3390/cells11233903.
https://www.mdpi.com/2073-4409/11/23/3903 - 5. Cucu I, Nicolescu MI, Busnatu ȘS, Manole CG. Dynamic involvement of telocytes in modulating multiple signaling pathways in cardiac cytoarchitecture. Int J Mol Sci. 2022; 23(10):5769. doi: 10.3390/ijms23105769.
https://www.mdpi.com/1422-0067/23/10/5769 - 6. Manole CG, Marinescu BG, Marta D, Nicolescu MI. Areas of cartilaginous and osseous metaplasia after experimental myocardial infarction in rats. Anat Rec (Hoboken). 2019; 302(6): 947-953. doi: 10.1002/ar.24010.
https://anatomypubs.onlinelibrary.wiley.com/doi/10.1002/ar.24010 - 7. Galrinho RD, Manole CG, Vinereanu D. Telocytes – a hope for cardiac repair after myocardial infarction. Maedica (Bucur). 2016; 11(4): 325-329.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5543526/pdf/maedica-11-325.pdf - 8. Manole CG, Simionescu O. The cutaneous telocytes. Adv Exp Med Biol. 2016; 913: 303-323. doi: 10.1007/978-981-10-1061-3_20.
https://link.springer.com/chapter/10.1007/978-981-10-1061-3_20 - 9. Manole CG, Cretoiu D. In memoriam: Professor Laurentiu M. Popescu (1944-2015). Clin Transl Med. 2015; 4(1): 29. doi: 10.1186/s40169-015-0070-5.
https://clintransmed.springeropen.com/articles/10.1186/s40169-015-0070-5 - 10. Kang Y, Zhu Z, Zheng Y, Wan W, Manole CG, Zhang Q. Skin telocytes versus fibroblasts: two distinct dermal cell populations. J Cell Mol Med. 2015; 19(11): 2530-9. doi: 10.1111/jcmm.12671.
https://onlinelibrary.wiley.com/doi/10.1111/jcmm.12671 - 11. Manole CG, Gherghiceanu M, Simionescu O. Telocyte dynamics in psoriasis. J Cell Mol Med. 2015; 19(7): 1504-19. doi: 10.1111/jcmm.12601.
https://onlinelibrary.wiley.com/doi/10.1111/jcmm.12601 - 12. Drăgoi Galrinho R, Ciobanu AO, Rimbas RC, Manole CG, Leena BM, Vinereanu D. New echocardiographic protocol for the assessment of experimental myocardial infarction in rats. Maedica (Bucur). 2015; 10(2): 85-90.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5327796/pdf/maedica-10-85.pdf - 13. Chen X, Zheng Y, Manole CG, Wang X, Wang Q. Telocytes in human oesophagus. J Cell Mol Med. 2013; 17(11): 1506-12. doi: 10.1111/jcmm.12149.
https://onlinelibrary.wiley.com/doi/10.1111/jcmm.12149 - 14. Qi G, Lin M, Xu M, Manole CG, Wang X, Zhu T. Telocytes in the human kidney cortex. J Cell Mol Med. 2012; 16(12): 3116-22. doi: 10.1111/j.1582-4934.2012.01582.x.
https://onlinelibrary.wiley.com/doi/10.1111/j.1582-4934.2012.01582.x - 15. Manole CG, Cismaşiu V, Gherghiceanu M, Popescu LM. Experimental acute myocardial infarction: telocytes involvement in neo-angiogenesis. J Cell Mol Med. 2011; 15(11): 2284-96. doi: 10.1111/j.1582-4934.2011.01449.x.
https://onlinelibrary.wiley.com/doi/10.1111/j.1582-4934.2011.01449.x - 16. Zheng Y, Li H, Manole CG, Sun A, Ge J, Wang X. Telocytes in trachea and lungs. J Cell Mol Med. 2011 Oct;15(10):2262-8. doi: 10.1111/j.1582-4934.2011.01404.x. PMID: 21810171; PMCID: PMC4394233.
https://onlinelibrary.wiley.com/doi/10.1111/j.1582-4934.2011.01404.x - 17. Popescu LM, Gherghiceanu M, Suciu LC, Manole CG, Hinescu ME. Telocytes and putative stem cells in the lungs: electron microscopy, electron tomography and laser scanning microscopy. Cell Tissue Res. 2011 Sep;345(3):391-403. doi: 10.1007/s00441-011-1229-z.
https://link.springer.com/article/10.1007/s00441-011-1229-z - 18. Enciu AM, Nicolescu MI, Manole CG, Mureşanu DF, Popescu LM, Popescu BO. Neuroregeneration in neurodegenerative disorders. BMC Neurol. 2011; 11: 75. doi: 10.1186/1471-2377-11-75.
https://bmcneurol.biomedcentral.com/articles/10.1186/1471-2377-11-75 - 19. Popescu LM, Manole E, Serboiu CS, Manole CG, Suciu LC, Gherghiceanu M, Popescu BO. Identification of telocytes in skeletal muscle interstitium: implication for muscle regeneration. J Cell Mol Med. 2011; 15(6): 1379-92. doi: 10.1111/j.1582-4934.2011.01330.x.
https://onlinelibrary.wiley.com/doi/10.1111/j.1582-4934.2011.01330.x - 20. Gherghiceanu M, Manole CG, Popescu LM. Telocytes in endocardium: electron microscope evidence. J Cell Mol Med. 2010; 14(9): 2330-4. doi: 10.1111/j.1582-4934.2010.01133.x.
https://onlinelibrary.wiley.com/doi/10.1111/j.1582-4934.2010.01133.x - 21. Popescu LM, Manole CG, Gherghiceanu M, Ardelean A, Nicolescu MI, Hinescu ME, Kostin S. Telocytes in human epicardium. J Cell Mol Med. 2010; 14(8): 2085-93. doi: 10.1111/j.1582-4934.2010.01129.x.
https://onlinelibrary.wiley.com/doi/10.1111/j.1582-4934.2010.01129.x - 22. Popescu LM, Gherghiceanu M, Manole CG, Faussone-Pellegrini MS. Cardiac renewing: interstitial Cajal-like cells nurse cardiomyocyte progenitors in epicardial stem cell niches. J Cell Mol Med. 2009; 13(5): 866-86. doi: 10.1111/j.1582-4934.2009.00758.x.
https://onlinelibrary.wiley.com/doi/10.1111/j.1582-4934.2009.00758.x - 23. Suciu L, Popescu LM, Regalia T, Ardelean A, Manole CG. Epicardium: interstitial Cajal-like cells (ICLC) highlighted by immunofluorescence. J Cell Mol Med. 2009 Apr;13(4):771-7. doi: 10.1111/j.1582-4934.2009.00756.x.
https://onlinelibrary.wiley.com/doi/10.1111/j.1582-4934.2009.00756.x
Member of
- Bucharest Medical Council
- Romanian Medical Council
- Romanian Society of Dermatology
Values
Integrity
Dr. Manole has a rich case history and extensive clinical experience in the diagnosis, prevention, and management of various dermatological and venereological pathologies in both women and men.
Compassion
Each patient is perceived and treated with sensitivity and empathy, both combined with the desire to help and promote the patient's well-being, to find a solution to patient’s situation.
Innovation
Dr. Manole embraces change, encourages innovation, and remains continuously informed about advances in the field of dermatological health for the benefit of his patients.